Antibodies Protect Against HIV in Mice

Researchers have devised a gene transfer technique in mice that, with a single injection, protects the immune cells that HIV targets. With further development, the approach may prove effective at helping to prevent HIV infection in people.

Most vaccines work by triggering the immune system to produce antibodies to help beat back infections. But a vaccine for HIV has been elusive. Proteins on the surface of HIV mutate rapidly, changing shape and preventing most antibodies from latching onto the virus.

Scientists have discovered several antibodies that can neutralize HIV. They've gained important insights into how they bind to the virus and why they're effective. But designing a vaccine that prompts the human immune system to generate such antibodies and mount an effective attack remains a difficult challenge.

A team of researchers led by Drs. Alejandro Balazs and David Baltimore at the California Institute of Technology decided to pursue a different strategy—one that doesn't require the immune system to generate antibodies. Their work was partly supported by NIH's National Institute of Allergy and Infectious Disease (NIAID). Nature.

The scientists began with a virus capable of expressing high levels of full-length human antibodies when injected into muscle. They modified the virus by inserting the genes that code for an HIV-neutralizing antibody called b12. When the virus was injected into mouse leg muscle, the mice produced high levels of antibodies for at least a year.


 Get The Latest By Email

Weekly Magazine Daily Inspiration

The researchers next tested whether the technique could protect against HIV. Mice aren't susceptible to HIV, so the researchers used specialized mice with human CD4 cells, the immune cells that HIV targets and infects. After exposure to the virus, mice expressing b12 antibodies showed none of the CD4 cell loss that control animals did.

The researchers tested other antibodies known to neutralize a broad range of HIV strains. Another antibody called VRC01, which was identified by scientists at NIH, produced results similar to b12. Both antibodies protected CD4 cells against HIV doses 100-fold higher than the levels that would infect most animals. This protection would be well beyond that needed to prevent HIV infection in humans.

into the body, and the immune system figures out how to make an antibody against it,” Balazs explains. We've taken that whole part out of the equation.

The team is now developing a plan to test the method in human clinical trials. If humans are like mice, then we have devised a way to protect against the transmission of HIV from person to person,” says Baltimore. and so the next step is to try to find out whether humans behave like mice. by Harrison Wein, Ph. D.


  • http://www. nih. gov/researchmatters/december2009/12072009hiv.

  • http://www. nih. gov/researchmatters/august2011/08292011hiv.

  • http://www. nih. gov/researchmatters/july2010/07192010antibodies.

  • http://www. nih. gov/researchmatters/february2007/02262007vaccine.

  • http://www. aidsinfo. nih.

Article Source:
 http://www.nih.gov/researchmatters/december2011/12122011hiv.htm

AVAILABLE LANGUAGES

English Afrikaans Arabic Chinese (Simplified) Chinese (Traditional) Danish Dutch Filipino Finnish French German Greek Hebrew Hindi Hungarian Indonesian Italian Japanese Korean Malay Norwegian Persian Polish Portuguese Romanian Russian Spanish Swahili Swedish Thai Turkish Ukrainian Urdu Vietnamese

follow InnerSelf on

facebook icontwitter iconyoutube iconinstagram iconpintrest iconrss icon

 Get The Latest By Email

Weekly Magazine Daily Inspiration

Monday, 24 July 2023 19:42

Today, mountains of calorie-rich (and often nutritionally poor) food and lakes of sugary beverages are readily available in much of the world. It’s no longer necessary to leave home — or even stand...

Wednesday, 26 May 2021 08:54

The term “exercise is medicine” is rightfully well publicised. It’s one of the best ways to stay healthy, yet medicine doesn’t work if you aren’t prepared to take it.

Saturday, 01 May 2021 08:12

High-intensity interval training (HIIT) workouts have become popular in recent years for a number of reasons. They don’t require as much time as a regular workout (some can take as little as 10...

Wednesday, 26 July 2023 17:18

Do you know why junk food is so addictive? Are you craving sweets yet? If you've ever wondered why junk food can be so addictive, you're not alone.

Thursday, 15 April 2021 07:13

As a species, humans are wired to collaborate. That’s why lockdowns and remote work have felt difficult for many of us during the COVID-19 pandemic.

Monday, 07 June 2021 08:07

Injury to the adult brain is all too common. A brain injury will often show up on brain scans as a well-defined area of damage. But often the changes to the brain extend far beyond the visible...

New Attitudes - New Possibilities

InnerSelf.comClimateImpactNews.com | InnerPower.net
MightyNatural.com | WholisticPolitics.com | InnerSelf Market
Copyright ©1985 - 2021 InnerSelf Publications. All Rights Reserved.